Her latest thing is Dead Like Me, one of the many "other" platform shows (I have television, okay?), but Christiana Applegate for me will always largely be Kelly Bundy. She also has an honorable mention for her great (she did win an Emmy) guest appearances as Rachel's sister on Friends. Reese Witherspoon also had a two episode stint, but Applegate was the real pro. Applegate is basically my age (down to weeks). Seems to have a good overall mentality too.
Health issues is not new for her. In 2008, she made the decision to remove both of her breasts in a double mastectomy because she not only got breast cancer but was found to have a gene that would make it very likely to come back even after treatment. And, she publicized her condition to spread the word, even though she had reconstructive surgery (breast implants) that didn't make it apparent without people being told.
She just announced that she has MS. Selma Blair, her co-star along with Cameron Diaz, in The Sweetest Thing has lived with it for some years now (with some physical problems). The other 1980s star that comes to mind, of course, is Family Ties guy. Many have these conditions, but of course, only a few have such wide fan bases with a certain special personal connection. To the degree celebrity does that. So, like so many, I give her best wishes.
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Thanks for your .02!